Compound of iron and nuclein and process of making same.



UNITED STATES PATENT OFFICE.

KARL SCHWIOKERATH, OF DETROIT, MICHIGAN.

COMPOUND OF IRON AND NUCLEIN AND PROCESS OF MAKING SAME.

SPECIFICATION forming part of Letters Patent No. 637,354, dated November21, 1899. Application filed October 6, 1898. Serial No. 692,782. (Nospecimens.)

T0 at whom it may concern:

Beit known that I, KARL SoHwIoKERATH, a subject of the King of Prussia,German Emperor, residing at Detroit, county of Wayne, State of Michigan,have invented a certain new and useful Improvement in Processes ofPreparing Compound of Nuclein and Iron and Product; and I declare thefollowing to be a full, clear, and exact description of the invention,such as will enable others skilled in the art to which it pertains tomake and use the same.

My invention relates to a process for and the manufacture of a newsoluble compound of nuclein and iron not heretofore known; and itconsists in the process and the compound as an article of manufacture,as is hereinafter described.

In order to form this compound, I dissolve about three hundred grams ofnuclein in about six liters of water, or suffieient Water to form asolution. To this is added an excess of alkali, which for the proportionspecified would be about one hundred and fifty grams of (preferably)sodium carbonate. The object of adding the alkali is to neutralize theacid character of the nuclein and to create an excess of alkali in thesolution. To this alkaline solution of nuclein I add about one hundredand five grams of iron-chloride solution of thirteen-per-cent. strengthdiluted with about two hundred cubic centimeters of water. The reactionwhich takes place on adding a solution of iron chloride to the solutionof nuclein containing an excess of alkali is the formation of ironhydroxide, which combines in stain nasccndi with the nuclein, formingthe combination of nuclein and iron, as set forth, and which isthereafter precipitated by the addition of about twice its volume ofalcohol and quantum su jicit of a concentrated neutral-salt solution, assodium chloride. The precipitate is washed with alcohol, pressed,- anddried. It is of a light cinnamon color and contains about four andone-half per cent. of iron. It is soluble in Water and dilute alcoholand is not precipitated by alkalies nor attacked by dilute acids. I havefound that artificial gastric j nice has no influence upon it. It isperfectly tasteless and is not directly precipitated by ammoniumsulphide, which merely changes the color to a light green, which onstanding grows darker. The fact that this compound is not affected bygastric juice, is tasteless, and free from astringency renders it ofgreat value as a pharmaceutical preparation.

Of course any multiple or division of the proportions given may be used.

What I claim is 1. The herein-described method of prepar ing a compoundof nuclein and iron, consist ing in adding to an alkaline solution ofnuclein a soluble ferric salt in solution, precipitating the resultantcompound of nuclein and iron, separating the precipitate, washing it,and drying it, substantially as described.

2. As a new product,'the new soluble compound of nuclein and ironcontaining about four and one-half per cent. of iron, and about four andone-half per cent. of phosphorus in- -eluded in the nuclein, and whichis not precipitated by alkalies, ammonium sulphide, nor dilute acids, istasteless and free from astringenoy, substantially as set forth.

In testimony whereof I sign this specifioa tion in the presence of twowitnesses.

KARL SOHWIOKERATH.

\Vitnesses:

R. A. PARKER, MARION A. REEVE.

